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生物毒素肾损伤的防治策略
作者:冯哲 文浩 
单位:100853  北京 解放军总医院肾脏病科/解放军肾脏病研究所/肾脏疾病国家重点实验室/国家慢性肾病临床医学研究中心(冯哲、文浩) 
关键词:生物毒素 急性肾损伤 血液净化治疗 
分类号:R691.6
出版年,卷(期):页码:2019,44(7):550-554
摘要:

随着人类活动的增多,生物毒素中毒逐渐成为一个严重的健康问题。生物毒素通常分为细菌毒素、真菌毒素、海洋生物毒素、动物毒液、肠毒素、外毒素等,多种毒素均可导致肾功能下降,甚至导致急性肾衰竭。生物毒素肾损伤涉及多种病理生理机制,病情凶险,未及时恰当治疗常导致较高的病死率。血液净化疗法在救治生物毒素肾损伤的患者中发挥了核心作用。该文就我国常见的生物毒素,包括毒蕈毒素、鱼胆、蛇毒和蜂毒等导致的急性肾损伤的防治现状进行述评,旨在使中国肾脏病学者和专科医师明确生物毒素肾损伤的防治重点,规范生物毒素肾损伤的防治策略。

With the increase of human activities, biotoxin poisoning has gradually become a serious health problem. Biotoxins are usually classified into bacterial toxins, mycotoxins, marine toxins, animal venoms, enterotoxins, exotoxins, etc. A variety of toxins can cause impaired renal function and even lead to acute renal failure. The biotoxin-induced kidney injury is a dangerous clinical condition involving a variety of pathophysiological mechanisms. Failure to treat properly in time often leads to higher mortality. Blood purification therapy plays a central role in the treatment of patients with biotoxin-induced renal injury. The present paper reviews the current status of prevention and treatment of acute renal injury caused by common biotoxins in China, including poisonous mushrooms, fish gall, snake venom and bee stings. The purpose of this review is to make Chinese nephrologists and specialists clear the prevention and treatment of biotoxin-induced renal injury, and standardize the prevention and treatment strategy of biotoxin-induced kidney injury.

基金项目:
国家自然科学基金(81670671,81670694,81770664)
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