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基于体表面积和体重的个体化对比剂方案在冠脉CT血管造影中的应用价值
作者:杨琴 何其舟 余飞 张艳丽 斯光晏 
单位:646000  四川泸州  西南医科大学附属中医医院放射影像科(杨琴、何其舟、余飞、张艳丽、斯光晏) 
关键词:冠脉CT血管造影 体表面积 体重 造影剂 强化程度 强化效果 
分类号:R543.304.5
出版年,卷(期):页码:2018,43(2):135-139
摘要:

[摘要]  目的  探讨基于体表面积(BSA)和体重(BW)调节个体化对比剂注射方案对冠状动脉强化程度及强化效果的影响。方法 选取2016112月西南医科大学附属中医医院门诊疑似冠心病患者300例,随机分为对照组(固定注射体积及流速组)BSA调节组和BW调节组,每组各100例。三组患者均行冠脉CT血管造影(CTA),对比分析三组冠状动脉强化程度、冠脉CTA成像质量、对比剂剂量及流速,并评价其安全性。结果  BSA调节组与BW调节组冠状动脉强化值均明显大于对照组(P<0.05),而BSA调节组冠状动脉强化值明显大于BW调节组(P<0.05),且其标准差明显小于BW调节组(P<0.05)BSA调节组冠脉CTA评分明显高于对照组(P<0.05),但BSA调节组与BW调节组之间差异无统计学意义(P>0.05)BW调节组与对照组之间差异亦无统计学意义(P>0.05)。与对照组比较,BW调节组和BSA调节组对比剂剂量、流速均明显下降(P<0.05),且BW调节组与BSA调节组之间差异无统计学意义(P>0.05)。三组安全性指标差异无统计学意义(P>0.05)结论 基于BSA设计个体化对比剂注射方案,既可减少冠脉成像对比剂用量和流速,又能提高冠脉强化程度及强化效果。

[Abstract]  Objective  To explore the effect of individualized contrast agent injection regimen on coronary artery enhancement based on body surface area (BSA) and body weight (BW). Methods  Totally 300 patients with suspected coronary heart disease from January to December 2016 in our hospital were randomly divided into three groups: control group (the injection volume and flow rate were fixed), BSA adjustment group and BW adjustment group. The patients were detected by CTA, and the degree and quality of coronary artery enhancement, the amount and flow rate of contrast agent, and the safety were analyzed in the three groups. Results  The coronary artery enhancement value of the BSA adjustment group and the BW adjustment group was significantly higher than that of the control group (P<0.05). The coronary enhancement in the BSA adjustment group was significantly higher than that of the BW adjustment group. Moreover, the standard deviation of the BSA adjustment group was significantly lower than that of the BW adjustment group (P<0.05). The CTA score of the BSA adjustment group was significantly higher than that of the control group (P<0.05). However, there was no significant difference between the BW adjustment group and BSA adjustment group or the control group (P>0.05). The contrast agent dosage and flow rate was significantly higher in the control group than in the BSA adjustment group and BW adjustment group (P<0.05). However, there was no significant difference between the BW adjustment group and BSA adjustment group (P>0.05). Also, there was no significant difference in safety index between the three groups (P>0.05). Conclusion  The individualized contrast agent injection program based on BSA adjustment could not only reduce the amount of coronary imaging contrast agent and flow rate, but also improve the degree and effect of coronary artery enhancement. It could be expected to become a technical means for screening, early diagnosis, and even early intervention in early coronary heart disease.

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