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期刊名称: 解放军医学杂志
主管单位: 中央军委后勤保障部卫生局
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国际标准刊号:ISSN 0577-7402
国内统一刊号:CN 11-1056/R
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帕金森病的发病机制、诊断标准及治疗策略
信息来源:  发布日期:2018/9/17 8:41:09

[摘要] 帕金森病(PD)是一种好发于中老年人的常见的神经系统退行性疾病。我国65岁以上人群PD患病率为1700/10万,且随年龄增长逐渐升高,给家庭和社会造成了沉重负担。PD的发生是多种因素如遗传、环境、年龄老化等综合作用的结果,α-突触核蛋白、氧化应激、DNA甲基化、神经营养因子、线粒体自噬、神经递质、神经炎症、miRNA、钙的细胞毒作用、免疫学异常、细胞凋亡等多种机制,均可引起黑质多巴胺能神经元变性而导致PD发病。本文重点介绍导致黑质多巴胺能神经元变性的致病因素,以及PD的识别、防治策略与技术。
[关键词] 帕金森病;多巴胺能神经元;诊断;治疗策略
[中图分类号] R742.5    [文献标志码] A    [文章编号] 0577-7402(2018)08-0631-05
[DOI] 10.11855/j.issn.0577-7402.2018.08.01


Pathogenesis, diagnosis and treatment strategies of Parkinson's disease
LIANG Jian-qing
Department of Diagnosis of Traditional Chinese Medicine, School of Basic Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
This work was supported by the National Natural Science Foundation of China (81573899, 81660767), the Open Foundation of Key Laboratory of Dunhuang Medicine and Transformation co-constructed by the Ministry of Education and Gansu Province (DHYX1516-08), and the Scientific Research Fund for Young and Middle-Aged Scholars of Gansu University of Traditional Chinese Medicine (ZQ2015-17)


[Abstract] Parkinson's disease (PD) is a common degenerative disease of the middle-aged and old people. The prevalence of PD in the people over 65-years is 1700/100 thousand, and is increasing with age, which has caused a heavy burden to the family and society. PD is a comprehensive effect of various factors such as genetic factors, environmental factors, aging, alpha synuclein, oxidative stress, DNA methylation, neurotrophic factor, mitochondrial autophagy, immunological abnormality, neurotransmitters, nerve inflammation, miRNA, calcium cytotoxicity, and apoptosis, which can cause the degeneration of dopaminergic neuron of substantia nigra, and thereby causes the disease. The pathogenic factors leading to degeneration of dopaminergic neuron in substantia nigra, as well as the strategies and techniques for identification, prevention and treatment of PD has been especially introduced in present paper.
[Key words] Parkinson's disease; dopaminergic neuron; diagnosis; treatment strategy

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